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Updated: Jan 20, 2026

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats
Published on: March 7, 2025
Loculated subretinal fluid after pneumatic vitreolysis
Jason N Crosson1, Meredith E Thomley1,2, Clement K Chan3,4
1Retina Consultants of Alabama, The University of Alabama at Birmingham, 700 18th St. S #707, Birmingham, AL, 35294, USA.
Pneumatic vitreolysis (PVL) can cause loculated subretinal fluid, a rare complication. This case study shows the fluid eventually resolved without impacting long-term vision.
Area of Science:
- Ophthalmology
- Retinal Surgery
Background:
- Vitreomacular traction (VMT) can cause decreased visual acuity.
- Pneumatic vitreolysis (PVL) is a surgical technique used to treat VMT.
Observation:
- A 74-year-old female with VMT experienced decreased visual acuity.
- PVL treatment led to successful VMT release but caused a novel complication: loculated subretinal fluid.
- This fluid persisted for 14 months before spontaneous resolution.
Findings:
- Loculated subretinal fluid is an unusual complication of PVL.
- Despite persistent fluid, no adverse visual outcomes were observed.
- Visual acuity ultimately improved after fluid resolution.
Implications:
- This case highlights an uncommon but benign complication of PVL.
- It suggests that persistent subretinal fluid may resolve over time without permanent vision loss.
- Ophthalmologists should be aware of this potential complication when performing PVL.
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