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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Acquired factor VIIIC deficiency due to circulating factor VIIIC inhibitors

Y K Kueh1, D R Koh, T B Chan

  • 1Department of Medicine, National University Hospital, Singapore.

Annals of the Academy of Medicine, Singapore
|October 1, 1988
PubMed

The management of patients with Factor VIIIC inhibitor is frequently a therapeutic challenge. Treatment is often individualized. We describe 3 patients, nonhaemophilic adults, with bleeding diatheses caused by a circulating inhibitor to Factor VIIIC. One patient had long standing rheumatoid arthritis. The other two did not have any apparent underlying disease, although one of them had an antecedent antecedent phenylbutazone injection for arthralgias. Prednisolone was prescribed for two patients which resulted in rapid clinical improvement and the eventual normalization of Factor VIIIC activity. The role and rationale of immunosuppressive therapy in Factor VIIIC inhibitor is reviewed.

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