Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

Anesthesia-induced developmental neurotoxicity (AIDN) research has focused on rodents, which are not broadly applicable to humans. Non-human primate models are more relevant, but are cost-prohibitive and difficult to use for experimentation. The piglet, in contrast, is a clinically relevant, practical animal model ideal for the study of anesthetic...

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

This study explores the novel use of enzyme-based microelectrode array (MEA) technology to monitor in vivo neurotransmitter activity in piglets. The hypothesis was that glutamate dysregulation contributes to the mechanism of anesthetic neurotoxicity. Here, we present a protocol to adapt MEA technology to study the mechanism of anesthesia-induced...

An Assay to Study Effect of Test Compound against PolyQ-Mediated Neurotoxicity in Worms

An Assay to Study Effect of Test Compound against PolyQ-Mediated Neurotoxicity in Worms

In this video, we describe a method to evaluate the neuroprotective effect of a test compound, astragalan, on neuronal survival in Caenorhabditis elegans from polyQ-mediated neurotoxicity. The assay uses Caenorhabditis elegans expressing the abnormally expanded polyQ repeats fused to GFP in their ASH neurons to measure neuronal survival following test compound...

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Human induced pluripotent stem cells (hiPSCs) are considered a powerful tool for drug and chemical screening and for the development of new in vitro models for toxicity testing, including neurotoxicity. Here, a detailed protocol for the differentiation of hiPSCs into neurons and glia is...

Three-electrode Coin Cell Preparation and Electrodeposition Analytics for Lithium-ion Batteries

Three-electrode Coin Cell Preparation and Electrodeposition Analytics for Lithium-ion Batteries

Three-electrode cells are useful in studying the electrochemistry of lithium-ion batteries. Such an electrochemical setup allows the phenomena associated with the cathode and anode to be decoupled and examined independently. Here, we present a guide for construction and use of a three-electrode coin cell with emphasis on lithium plating...

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Microglia (immune cells of the brain), are used as a surrogate biosensor to determine how nanoparticles influence neurotoxicity. We describe a series of experiments designed to assay microglial response to nanoparticles and exposure of hypothalamic neurons to supernatant from activated microglia to determine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A little goes a long way: Strategies to support nursing staff amid COVID-19.

Nursing·2022

Same author

Alcohol use and binge drinking in baccalaureate nursing students: A descriptive study.

Journal of professional nursing : official journal of the American Association of Colleges of Nursing·2022

Same author

Local anesthetic systemic toxicity: What nurses should know.

Nursing·2021

Same author

Assessing Postvoid Residual to Identify Risk for Urinary Complications Post Stroke.

The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses·2020

Same author

The Effect of Listening to Music on Postoperative Pain in Adult Orthopedic Patients.

Journal of holistic nursing : official journal of the American Holistic Nurses' Association·2018

Same author

The Importance of Educating Patients With Stroke About Vitamin D.

The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses·2017

Search research articles

Related Experiment Video

Updated: Jan 20, 2026

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity AIDN: A Translational Neuroscience Approach

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity AIDN: A Translational Neuroscience Approach

Published on: June 11, 2017

Lithium-Induced Neurotoxicity: A Case Study.

Melissa A Schneider¹, Sonya S Smith

¹Sonya S. Smith, BSN RN, is Staff Nurse, Wellspan York Hospital, York, PA.

The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses

|August 31, 2019

Summary

This summary is machine-generated.

Lithium toxicity syndrome can cause neurological deficits. Early recognition is crucial to prevent irreversible neurological symptoms and potential death.

More Related Videos

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Published on: May 12, 2018

An Assay to Study Effect of Test Compound against PolyQ-Mediated Neurotoxicity in Worms

An Assay to Study Effect of Test Compound against PolyQ-Mediated Neurotoxicity in Worms

Related Experiment Videos

Last Updated: Jan 20, 2026

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity AIDN: A Translational Neuroscience Approach

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity AIDN: A Translational Neuroscience Approach

Published on: June 11, 2017

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

Published on: May 12, 2018

An Assay to Study Effect of Test Compound against PolyQ-Mediated Neurotoxicity in Worms

An Assay to Study Effect of Test Compound against PolyQ-Mediated Neurotoxicity in Worms

Area of Science:

Neurology
Toxicology
Pharmacology

Background:

Identifying the etiology of neurological deficits can be diagnostically challenging.
Neurological presentations often require a broad differential diagnosis.

Observation:

This case study highlights a rare condition presenting with neurological deficits.
The condition discussed is lithium toxicity syndrome.

Findings:

Lithium toxicity syndrome, though uncommon, should be considered in patients with unexplained neurological deficits and a history of lithium use.
Delayed diagnosis of lithium toxicity can lead to irreversible neurological damage.

Implications:

Early identification and management of lithium toxicity are essential to prevent long-term neurological sequelae.
Syndrome of irreversible lithium-effectuated neurotoxicity (SILE) can significantly impair quality of life or be fatal.