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Related Experiment Video

Updated: Jan 20, 2026

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Differences in edge artifacts between 68Ga- and 18F-PET images reconstructed using point spread function correction.

Shinji Amakusa1, Koki Matsuoka2, Shingo Baba3

  • 1Department of Radiological Technology, Koga Hospital 21, Kurume.

Nuclear Medicine Communications
|August 31, 2019
PubMed
Summary

Gallium-68 (Ga) PET imaging shows fewer edge artifacts than Fluorine-18 (F) PET imaging when using point spread function correction, likely due to differences in positron range.

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiochemistry

Background:

  • Edge artifacts are a known issue in Fluorine-18 Positron Emission Tomography (F-PET) with point spread function (PSF) correction.
  • The longer positron range of Gallium-68 (Ga) compared to F is hypothesized to influence these artifacts.

Purpose of the Study:

  • To investigate and clarify the differences in edge artifacts between Ga-PET and F-PET when employing PSF correction algorithms.

Main Methods:

  • Utilized a NEMA IEC body phantom filled with either Ga or F solutions.
  • Acquired PET data over 90 minutes using a Biograph 16 scanner.
  • Reconstructed images using OSEM with PSF correction and analyzed visually and via recovery coefficients.

Main Results:

  • Ga-PET images exhibited less prominent ring-like edge artifacts compared to F-PET.
  • Ga-PET showed lower overshoot in radioactivity profiles, while F-PET displayed high overshoots.
  • Absolute recovery coefficients were smaller for Ga-PET than F-PET.

Conclusions:

  • Ga-PET demonstrates reduced edge artifacts and smaller radioactivity overshoots compared to F-PET.
  • The distinct positron ranges of Ga and F likely account for the observed differences in edge artifacts with PSF correction.