Related Experiment Video
Updated: Jan 20, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Mast Cell Activation Syndrome: Tools for Diagnosis and Differential Diagnosis
1Division of Allergy, Mayo Clinic, Rochester, Minn.
Abstract:
The current consensus diagnostic criteria for mast cell activation syndrome(s) (MCAS[s]) were first established in 2012 and updated in 2019. This diagnosis has been attached to multiple medical conditions not intended as part of the diagnosis. In this article, the diagnostic criteria are reviewed and other diseases in the differential diagnosis outlined. The goal of this review is to provide a tool for evaluation of patients with conditions that can mimic MCAS. Furthermore, the potential role for hereditary alpha-tryptasemia in this group of disorders is discussed.
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