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Related Concept Videos

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas07:43

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Here, we present a two-dimensional gel electrophoresis (2DE) coupled with mass spectrometry (MS) to separate and identify human pituitary adenoma tissue proteome, which presents a good and reproducible 2DE pattern. Many proteins are observed in each 2DE spot when analyzing complex cancer proteome with the use of high-sensitivity...
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Related Experiment Video

Updated: Jan 20, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Surgery for Pediatric Pituitary Adenomas.

Alexandria C Marino1, Davis G Taylor1, Bhargav Desai1

  • 1Department of Neurological Surgery, University of Virginia Health Sciences Center, PO Box 800212, Charlottesville, VA 22908, USA.

Neurosurgery Clinics of North America
|September 1, 2019
PubMed
Summary

Pediatric pituitary adenomas often present as secretory tumors, differing from adult cases. Transsphenoidal surgery is effective for Cushing disease and gigantism in children, despite anatomical challenges.

Keywords:
ACTHCushing diseaseGrowth hormonePediatricPituitary adenomasProlactinomaTranssphenoidal

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Area of Science:

  • Pediatric neurosurgery
  • Endocrinology
  • Pediatric oncology

Background:

  • Pituitary adenomas are rare central nervous system tumors in children.
  • Pediatric pituitary adenomas exhibit distinct clinical manifestations compared to adults, often presenting as clinically secretory tumors.
  • Understanding these differences is crucial for appropriate diagnosis and management in pediatric patients.

Purpose of the Study:

  • To review the unique aspects of pituitary adenoma presentation and management in children.
  • To highlight the role of transsphenoidal surgery in pediatric pituitary adenomas, particularly for specific conditions.
  • To assess the safety and efficacy of surgical interventions in the pediatric population.

Main Methods:

  • Review of existing literature on pediatric pituitary adenomas.
  • Analysis of clinical presentations, treatment modalities, and outcomes in children.
  • Focus on surgical approaches, specifically transsphenoidal surgery.

Main Results:

  • Pediatric patients more frequently present with clinically secretory pituitary adenomas compared to adults.
  • Transsphenoidal surgery is a viable and effective treatment for pediatric Cushing disease and gigantism.
  • While anatomical challenges exist in children, transsphenoidal surgery can be performed safely with low complication rates.

Conclusions:

  • Pituitary adenomas in children require specialized consideration due to differing presentations and developmental factors.
  • Transsphenoidal surgery is a safe and effective therapeutic option for select pediatric pituitary adenomas, including those causing Cushing disease and gigantism.
  • Further research into optimizing surgical techniques and long-term outcomes in pediatric populations is warranted.