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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer07:45

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Patient-derived xenograft (PDX) models and transplantable genetically engineered mouse models faithfully recapitulate human disease and are preferred models for basic and translational breast cancer research. Here, a method is described to orthotopically transplant breast tumor fragments into the mammary fat pad to study tumor biology and evaluate drug...
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Activation of latent mutations with adenovirus-Cre into the mammary ductal system results in a clinically relevant metastatic breast cancer. Incorporation of a YFP promoter allows tracking of distal metastatic tumor cells. This model is useful to study latent metastasis, anti-tumor immunity, and for designing novel immunotherapies to treat breast...
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This prospective study evaluated the implementation of a novel, single-port, robotic platform in oncoplastic breast-conserving surgery for malignant lesions. The primary endpoint focused on technical success, defined as the achievement of tumor-free resection margins confirmed by intraoperative frozen-section histopathology, with secondary assessment of aesthetic outcomes and life quality score of...
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Related Experiment Video

Updated: Jan 20, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Breast pyoderma gangrenosum

Anissa Zaouak1, Amal Chamli1, Sarra Boufarguine1

  • 1Habib-Thameur Hospital, Dermatology Department, Research Unit "Genodermatoses and cancers LR12SP03", Tunis, Tunisia.

Presse Medicale (Paris, France : 1983)
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