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Related Experiment Videos

The coalescent process in models with selection and recombination.

R R Hudson1, N L Kaplan

  • 1National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

Genetics
|November 1, 1988
PubMed
Summary

Investigating neutral gene evolution linked to selection, this study found that statistical models for linked loci are simple modifications of fully linked models. Drosophila Adh gene data partially supports balancing selection theory.

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Area of Science:

  • Population genetics
  • Molecular evolution
  • Genomics

Background:

  • Understanding gene evolution requires analyzing neutral loci linked to selected loci.
  • The alcohol dehydrogenase (Adh) gene in Drosophila melanogaster is a model system for studying genetic variation.

Purpose of the Study:

  • To investigate the statistical properties of genealogical processes for neutral genes linked to selected loci.
  • To compare theoretical predictions with empirical sequence data from the Drosophila Adh region.

Main Methods:

  • Mathematical modeling of genetic drift and selection.
  • Analysis of DNA sequence data from Drosophila melanogaster Adh alleles.
  • Comparison of observed nucleotide diversity patterns with theoretical expectations.

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Main Results:

  • The statistical properties of neutral loci linked to selected loci can be modeled as simple modifications of completely linked loci.
  • Sequence data from Adh Fast and Slow alleles showed spatial distribution of nucleotide differences consistent with balancing selection.
  • Differences among Slow alleles at the Adh locus did not align well with the simple balancing selection model.

Conclusions:

  • The theory provides a useful framework for understanding gene evolution at neutral loci linked to selection.
  • Balancing selection may play a role in maintaining allozyme variation at the Adh locus in Drosophila.
  • Further refinement of models is needed to explain nucleotide diversity patterns among closely related alleles.