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Related Experiment Video

Updated: Jan 20, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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PET/CT Specificities in 90Y Imaging Post Radioembolization.

Walrand Stephan1, Hesse Michel1

  • 1Nuclear Medicine, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium.

PET Clinics
|September 2, 2019
PubMed
Summary

This review addresses challenges in imaging yttrium-90 (90Y) positron emission tomography/computed tomography (PET/CT) after liver radioembolization. It guides phantom studies, activity quantification, tumor dosimetry, and extrahepatic delivery assessment.

Keywords:
DosimetryLiver radioembolizationPETQuantificationYttrium-90

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Medical Imaging

Background:

  • Liver radioembolization uses yttrium-90 (90Y) microspheres.
  • Accurate imaging is crucial for treatment assessment and safety.
  • Positron emission tomography/computed tomography (PET/CT) is a key imaging modality.

Purpose of the Study:

  • To review the challenges associated with 90Y PET/CT imaging after liver radioembolization.
  • To identify specificities of different PET systems relevant to 90Y imaging.
  • To provide guidance for clinical routine applications.

Main Methods:

  • Comprehensive literature review focusing on 90Y PET/CT.
  • Analysis of technical aspects and limitations of various PET systems.
  • Discussion of clinical applications and their imaging requirements.

Main Results:

  • Identified specific challenges in 90Y PET/CT, including scatter, partial volume effects, and system-specific characteristics.
  • Highlighted the importance of phantom validation studies for accurate quantification.
  • Demonstrated the need for careful assessment of intrahepatic activity and tumor dosimetry.

Conclusions:

  • Standardized phantom studies are essential for validating 90Y PET/CT systems.
  • Accurate quantification of intrahepatic 90Y activity is feasible with appropriate methods.
  • PET/CT is vital for assessing tumor response and ensuring safe delivery of 90Y spheres.