Related Experiment Video

Updated: Jan 20, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

3.4K

The Evolution from Hypertension to Heart Failure

Matthew J Sorrentino1

  • 1Department of Medicine, Section of Cardiology, University of Chicago Medicine, 5841 South Maryland Avenue, MC 6080, Room B607, Chicago, IL 60637, USA.

Heart Failure Clinics
|September 2, 2019
PubMed

Insights

Treating hypertension and adopting healthy lifestyle changes like exercise and weight loss can prevent hypertensive heart disease and heart failure. These interventions improve heart function and reduce risks.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Heart Failure Studies

Background:

  • Hypertensive heart disease encompasses diastolic dysfunction, left ventricular hypertrophy, and heart failure.
  • Heart failure can arise from ischemic heart disease or the progression of diastolic dysfunction.
  • Diastolic dysfunction can lead to heart failure with preserved ejection fraction or reduced ejection fraction.

Purpose of the Study:

  • To review the impact of hypertension management on heart failure development.
  • To explore the role of lifestyle modifications in improving cardiac function.

Main Methods:

  • Review of clinical trials on hypertension treatment.
  • Analysis of studies on lifestyle modifications (exercise, weight loss) and diastolic function.

Main Results:

  • Hypertension treatment trials demonstrate prevention of heart failure.
  • Lifestyle changes, including exercise and weight loss, enhance diastolic function.
  • These modifications reduce the overall risk of developing heart failure.

Conclusions:

  • Effective management of hypertension is crucial for preventing hypertensive heart disease.
  • Lifestyle interventions are effective in improving cardiac diastolic function and mitigating heart failure risk.

Keywords:
Diastolic dysfunctionHeart failure with preserved ejection fraction (HFpEF)Heart failure with reduced ejection fraction (HFrEF)Left ventricular hypertrophy (LVH)

More Related Videos

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

1.9K
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension09:23

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

Published on: February 11, 2017

17.4K

Related Concept Videos

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

We present a protocol to induce and phenotype an acute right heart failure in a large animal model with chronic pulmonary hypertension. This model can be used to test therapeutic interventions, to develop right heart metrics or to improve the understanding of acute right heart failure...
3.4K
A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models07:49

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

The present protocol describes obtaining the pressure-volume relationship through transesophageal pacing, which serves as a valuable tool in evaluating diastolic function in mouse models of heart...
1.9K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
768
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension09:23

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

This protocol describes a surgical procedure to create a model for flow-induced pulmonary arterial hypertension (PAH) in rats and the procedures to analyze the principle hemodynamic and histological end-points in this...
17.4K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
720