Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

3.4K
We present a protocol to induce and phenotype an acute right heart failure in a large animal model with chronic pulmonary hypertension. This model can be used to test therapeutic interventions, to develop right heart metrics or to improve the understanding of acute right heart failure...
3.4K
A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models07:49

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

1.9K
The present protocol describes obtaining the pressure-volume relationship through transesophageal pacing, which serves as a valuable tool in evaluating diastolic function in mouse models of heart...
1.9K
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension09:23

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

17.4K
This protocol describes a surgical procedure to create a model for flow-induced pulmonary arterial hypertension (PAH) in rats and the procedures to analyze the principle hemodynamic and histological end-points in this...
17.4K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

768
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
768
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

3.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

720
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
720

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incremental Prognostic Value of Cardiac Magnetic Resonance Beyond Biomarker Staging in Transthyretin Cardiac Amyloidosis.

European heart journal. Cardiovascular Imaging·2026
Same author

Sodium-Glucose Cotransporter 2 Inhibitor Following Left Ventricular Assist Device Implantation: A Randomized Controlled Trial.

JACC. Heart failure·2026
Same author

A Rare Intracardiac Manifestation of an Aggressive Malignant Peripheral Nerve Sheath Tumor in a Young Adult.

CASE (Philadelphia, Pa.)·2026
Same author

Fully Automated versus Human Echocardiogram Interpretation in Transthyretin Amyloid Cardiomyopathy: The SCAN-MP Study.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2026
Same author

Diagnostic Accuracy of the Apical Sparing Ratio for Detecting Cardiac Amyloidosis in Left Ventricular Hypertrophy and Severe Aortic Stenosis: A Systematic Review and Meta-Analysis.

Echocardiography (Mount Kisco, N.Y.)·2026
Same author

Social Determinants of Health and Outcomes in Transthyretin Amyloid Cardiomyopathy.

The American journal of cardiology·2026
Same journal

Pulmonary Vascular Disease Across the Continuum: From Mechanisms to Precision Care.

Heart failure clinics·2026
Same journal

Long-term Complications of Pulmonary Embolism: Which Is the Optimal Follow-Up?

Heart failure clinics·2026
Same journal

Recent Advances in Pulmonary Hypertension Management.

Heart failure clinics·2026
Same journal

The Role of Machine Learning and Artificial Intelligence in Drug Discovery and Clinical Care of Pulmonary Hypertension.

Heart failure clinics·2026
Same journal

Portopulmonary Hypertension: Current Perspectives.

Heart failure clinics·2026
Same journal

Exercise Training and Cardiac Rehabilitation in Chronic Thromboembolic Pulmonary Hypertension.

Heart failure clinics·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

3.4K

Hypertension and Heart Failure.

Jeremy Slivnick1, Brent C Lampert2

  • 1Ohio State University Wexner Medical Center, 473 West 12th Avenue, Suite 200, Columbus, OH 43210, USA.

Heart Failure Clinics
|September 2, 2019
PubMed
Summary
This summary is machine-generated.

Hypertensive heart disease, from high blood pressure to heart failure, involves left ventricular hypertrophy. Early treatment of hypertension may reverse disease progression, preventing heart failure development.

Keywords:
HFpEFHFrEFHeart failureHeart failure drug therapyHypertensionLVH

More Related Videos

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

1.9K
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
09:23

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

Published on: February 11, 2017

17.4K

Related Experiment Videos

Last Updated: Jan 20, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

3.4K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

1.9K
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
09:23

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

Published on: February 11, 2017

17.4K

Area of Science:

  • Cardiology
  • Hypertension Research
  • Heart Failure Studies

Background:

  • Hypertensive heart disease encompasses conditions ranging from uncontrolled hypertension to heart failure.
  • Left ventricular hypertrophy is a key factor in the development of diastolic dysfunction and heart failure with preserved ejection fraction.
  • Understanding the progression to systolic heart failure in a subset of patients is crucial.

Purpose of the Study:

  • To elucidate the natural history and pathogenesis of heart failure in hypertensive heart disease.
  • To review the role of left ventricular hypertrophy in diastolic dysfunction.
  • To outline management strategies across all disease stages.

Main Methods:

  • Literature review on hypertensive heart disease.
  • Analysis of pathogenesis mechanisms leading to heart failure.
  • Discussion of current management strategies.

Main Results:

  • Left ventricular hypertrophy is the primary process leading to diastolic dysfunction.
  • Specific mechanisms contribute to the development of systolic heart failure in some patients.
  • Management strategies exist for all stages of hypertensive heart disease.

Conclusions:

  • Early intervention in hypertensive heart disease can lead to regression of cardiac changes.
  • Effective management can prevent or delay the onset of heart failure.
  • Targeting left ventricular hypertrophy is key in managing hypertensive heart disease.