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Lots of Movement in Gut and Parkinson's Research
Gabriela Mercado1, Patrik Brundin1
1Center for Neurodegenerative Sciences, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.
Trends in Endocrinology and Metabolism: TEM
|September 2, 2019
Abstract:
A new mouse model of Parkinson's disease (PD) demonstrates α-synuclein pathology spreading from the gut to the brain via the vagus nerve (Kim et al., Neuron, 2019). The pathology is associated with motor and non-motor behavioral deficits in wild-type mice. These findings support the idea that the gut could be a starting point for PD.