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Updated: Jan 10, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
Targeting inflammasome pathway towards therapeutics of neurodegenerative diseases
Wanli Smith1,2, Mali Jiang1, Jazlynn Meza1
1Department of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 21287.
Abstract:
Inflammasome, an intracellular protein complex, is a crucial regulator of the innate immune response defending against harmful insults. Increasing evidence indicates that activation of inflammasome pathway in brain cells plays a significant pathological role in neurodegenerative diseases. Targeting this pathway offers a promising strategy for developing novel treatments. Here, we review the wide-ranging involvement of inflammasome activation in neurodegenerative diseases and highlight current therapeutic strategies targeting this critical pathway.
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