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Transient Transduction of the Strobilated Forms of Echinococcus granulosus

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Published on: September 16, 2022

Designed Negative Feedback from Transiently Formed Catalytic Nanostructures.

Syed Pavel Afrose¹, Subhajit Bal¹, Ayan Chatterjee¹

¹Department of Chemical Sciences & Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER), Kolkata, Mohanpur, West Bengal, 741246, India.

Angewandte Chemie (International Ed. in English)

|September 3, 2019

Summary

This summary is machine-generated.

Researchers created a synthetic mimic of dynamic microtubule systems using amino acid functionalized lipids. This system exhibits substrate-induced self-assembly into helical nanostructures, demonstrating fuel-to-waste conversion and out-of-equilibrium dynamics.

Keywords:

catalysis dissipative self-assembly gels nanostructures systems chemistry

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Published on: January 31, 2014

Area of Science:

Supramolecular chemistry
Biomimetic systems
Nanotechnology

Background:

Microtubules are dynamic polymers crucial for cellular functions.
Their polymerization and depolymerization are regulated by substrate hydrolysis, leading to out-of-equilibrium states.
Understanding these dynamics is key to developing artificial dynamic systems.

Purpose of the Study:

To create a simple synthetic mimic of dynamic microtubule systems.
To investigate substrate-induced conformational changes and self-assembly.
To explore the creation of out-of-equilibrium states in artificial systems.

Main Methods:

Synthesis of amino acid functionalized lipids.
Characterization of substrate-induced conformational changes.
Observation of self-assembled nanostructures and their catalytic activity.

Main Results:

A synthetic system mimicking microtubule dynamics was developed.
Substrate-induced conformational changes led to transient helical nanostructures.
These nanostructures exhibited augmented catalytic activity, hydrolyzing the substrate and leading to their own destabilization.

Conclusions:

Amino acid functionalized lipids can form substrate-responsive self-assembled systems.
The system successfully mimics microtubule-like out-of-equilibrium behavior.
This work provides insights into designing synthetic dynamic and responsive materials.