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Updated: Jan 20, 2026
Atomic Emission Spectra; Hydrogen Emission Spectrum
Identification of bifucosylated glycoforms using low-energy CID spectra
András Ács1,2, Lilla Turiák1, Ágnes Révész1
1MS Proteomics Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, H-1117, Budapest, Hungary.
Abstract:
We have used tandem mass spectrometry (MS/MS)-based analysis of glycopeptides in order to identify the composition and structure of rare glycoforms. The results illustrate utility of low-energy MS/MS for structure identification. We have shown the presence of bifucosylated and trifucosylated glycoforms in human α-1-acid glycoprotein (AGP), a major plasma glycoprotein. Fucosylation in the case of AGP always occurs on the antennae; core fucosylation was not observed.
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