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Increased platelet function during frailty.

Blanca Hernández1, Eduardo Fuentes2, Iván Palomo2

  • 1Thrombosis Reasearch Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca, Talca, Chile; Magister in Biomedical Sciences, Universidad de Talca, Talca, Chile.

Experimental Hematology
|September 3, 2019
PubMed
Summary
This summary is machine-generated.

Frailty in older adults is linked to increased platelet activation, similar to aging and cardiovascular disease. This heightened platelet function, particularly P-selectin expression, is associated with diabetes mellitus in frail individuals.

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Area of Science:

  • Gerontology
  • Cardiovascular Science
  • Endocrinology

Background:

  • Frailty is strongly associated with cardiovascular diseases (CVD) and diabetes mellitus (DM).
  • Aging, CVD, and DM are all linked to increased platelet function.
  • Platelet activation plays a role in cardiovascular health and disease progression.

Purpose of the Study:

  • To investigate and evaluate platelet function in frail older adults compared to robust older adults and young controls.
  • To determine if frailty is associated with altered platelet activation markers.
  • To explore potential mechanisms linking frailty, diabetes, and platelet function.

Main Methods:

  • Study population: 37 older adults (16 frail, 21 robust) and 20 young controls.
  • Platelet function assessment: Aggregometry (aggregation) and flow cytometry (P-selectin expression).
  • Molecular analysis: Western blot for intraplatelet activation pathways; correlation with diabetes mellitus and hyperglycemia.

Main Results:

  • Aging increased platelet count, mean platelet volume, aggregation, and P-selectin expression compared to young adults.
  • Frail adults exhibited significantly higher P-selectin expression than robust adults.
  • Frail adults had a higher prevalence of DM and hyperglycemia, which in vitro, increased platelet aggregation and P-selectin expression.

Conclusions:

  • Frailty is associated with increased platelet activation, characterized by elevated P-selectin expression.
  • Diabetes mellitus and hyperglycemia may contribute to heightened platelet activation in frail individuals.
  • These findings highlight the role of platelet function in the pathophysiology of frailty and its comorbidities.