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Deep brain stimulation in Parkinson's disease: A multicentric, long-term, observational pilot study
Emma Scelzo1, Ettore Beghi2, Manuela Rosa1
1"Aldo Ravelli" Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan and Fondazione IRCCS Ca' Granda - Ospedale Maggiore, Milan, Italy.
Journal of the Neurological Sciences
|September 3, 2019
Summary
Deep brain stimulation (DBS) in Parkinson's disease (PD) patients showed lower rates of cognitive decline, urinary issues, and falls. While hospitalizations were higher, mortality risk remained similar, suggesting DBS benefits non-motor symptoms.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Deep brain stimulation (DBS) impact on Parkinson's disease (PD) non-motor symptoms is debated.
- Cognitive, urinary, and fall risks in PD patients undergoing DBS require further investigation.
Purpose of the Study:
- Compare rates of dementia, mild cognitive impairment (MCI), urinary issues, falls, hospitalizations, and mortality.
- Evaluate DBS efficacy in managing non-motor symptoms and complications in PD patients.
Main Methods:
- Retrospective pilot study across six Italian DBS centers.
- 91 PD patients receiving DBS compared with 91 matched controls on best medical treatment.
- Minimum one-year follow-up with data collected via a web-based system.
Main Results:
- Similar dementia risk; lower rates of MCI, urinary incontinence, nocturia, and falls in the DBS group.
- Higher PD-related hospital admissions in the DBS group, but not significant when excluding DBS surgery admissions.
- Lower non-PD-related hospitalizations and similar mortality risk in the DBS cohort.
Conclusions:
- DBS may improve management of non-motor symptoms and complications in advanced PD.
- Patients receiving DBS showed reduced MCI, urinary issues, and falls, with no increased dementia or mortality risk.
- Findings suggest DBS benefits for non-motor PD symptoms, requiring confirmation in prospective studies.