Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HIV heterogeneity and viral pathogenesis.

B A Castro1, C Cheng-Mayer, L A Evans

  • 1Cancer Research Institute, University of California School of Medicine.

AIDS (London, England)
|January 1, 1988
PubMed
Summary

Recent HIV research deepens understanding of virus diversity, infection targets, and control strategies. New findings on neutralization-resistant variants and macrophage reservoirs necessitate cautious vaccine development and refined HIV treatment approaches.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy.

Oncogene·2017
Same author

Efficacy of Soybean's Event DAS-81419-2 Expressing Cry1F and Cry1Ac to Manage Key Tropical Lepidopteran Pests Under Field Conditions in Brazil.

Journal of economic entomology·2016
Same author

Antigenic variations in the CD4 induced sites of the CCR5-tropic, pathogenic SHIVsf162p3 gp120 variants.

Journal of medical primatology·2003
Same author

Infection of macaques with a molecular clone, SHIVSF33A2, provides evidence for tissue specific variants.

Journal of medical primatology·2002
Same author

Baboons as an animal model for human immunodeficiency virus pathogenesis and vaccine development.

Immunological reviews·2002
Same author

The nuclear factor kappa B and Spl binding sites do not appear to be involved in virus suppression by CD8 T lymphocytes.

AIDS (London, England)·2002

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Significant advancements in understanding Human Immunodeficiency Virus (HIV) diversity and cellular targets.
  • Growing awareness of neutralization-resistant variants and antibody-mediated enhancement impacting vaccine development.
  • Recognition of mononuclear phagocyte system cells as critical reservoirs for HIV particles.

Purpose of the Study:

  • To synthesize recent findings in HIV research relevant to treatment and control strategies.
  • To highlight the complexities of HIV infection, including viral entry, cytopathic effects, and latency.
  • To identify critical unanswered questions for future HIV research.

Main Methods:

  • Review and synthesis of recent HIV research findings.

Related Experiment Videos

  • Analysis of viral mechanisms, including entry, cytopathic effects, and latency.
  • Identification of knowledge gaps and emerging research questions.

    • Main Results:

    • Enhanced understanding of HIV isolate diversity and susceptible host cells.
    • Caution advised for vaccine development due to neutralization-resistant variants and antibody-mediated enhancement.
    • Mononuclear phagocyte system cells identified as key reservoirs, impacting HIV persistence and dissemination.
    • New insights into cytokine induction of HIV and latent monocyte/macrophage infection.

    Conclusions:

    • Recent research has significantly advanced HIV knowledge but also revealed new challenges.
    • Understanding viral reservoirs and latency is crucial for effective HIV control.
    • Future research must address mechanisms of viral-induced cell death, latency, therapeutic targeting of reservoirs, and host survival mechanisms.