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Related Concept Videos

Visualization of a Cerebral Thrombus in a Mouse Using Micro-Computed Tomography Imaging02:05

Visualization of a Cerebral Thrombus in a Mouse Using Micro-Computed Tomography Imaging

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Source: Kim, D., et. al. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J. Vis. Exp. (2016)This video demonstrates visualization of cerebral thrombus in mice using micro-computed tomography (micro-CT) imaging. A cerebral thrombus mouse model is injected with fibrin-targeted gold nanoparticles acting as a contrasting agent. The mouse is placed on the bed of a micro-CT machine, and images are acquired from multiple angles.
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Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli13:10

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This protocol describes the application of combined near-infrared fluorescent (NIRF) imaging and micro-computed tomography (microCT) for visualizing cerebral thromboemboli. This technique allows the quantification of thrombus burden and evolution. The NIRF imaging technique visualizes fluorescently labeled thrombus in excised brain, while the microCT technique visualizes thrombus inside living animals using...
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The technique described herein offers a low cost and relatively simple method to simultaneously measure particle kinematics and turbulence in flows with low particle concentrations. The turbulence is measured using particle image velocimetry (PIV), and particle kinematics are calculated from images obtained with a high-speed camera in an overlapping...
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Imaging Studies III: Computed Tomography01:27

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Related Experiment Video

Updated: Jan 20, 2026

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
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Magnetic Particle Imaging meets Computed Tomography: first simultaneous imaging.

Patrick Vogel1,2, Jonathan Markert3,4, Martin A Rückert3

  • 1Department of Experimental Physics 5 (Biophysics), University of Würzburg, 97074, Würzburg, Germany. Patrick.Vogel@physik.uni-wuerzburg.de.

Scientific Reports
|September 4, 2019
PubMed
Summary
This summary is machine-generated.

Magnetic Particle Imaging (MPI) offers fast 3D visualization of magnetic materials. This study introduces the first hybrid MPI-CT scanner for simultaneous multimodal imaging, combining functional and anatomical data.

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Physics

Background:

  • Magnetic Particle Imaging (MPI) is an emerging tomographic technique.
  • MPI excels at fast, 3D visualization of magnetic materials.
  • Anatomical context typically requires a complementary imaging modality like Computed Tomography (CT).

Purpose of the Study:

  • To present the development and implementation of the first hybrid Magnetic Particle Imaging-Computed Tomography (MPI-CT) scanner.
  • To enable simultaneous data acquisition for multimodal imaging.
  • To integrate functional MPI data with anatomical CT information.

Main Methods:

  • Design and construction of a novel hybrid MPI-CT scanner.
  • Implementation of simultaneous data acquisition protocols.
  • Validation of the integrated system for multimodal imaging.

Main Results:

  • Successful development of the first hybrid MPI-CT scanner.
  • Demonstration of simultaneous data acquisition capabilities.
  • Proof-of-concept for combined functional and anatomical imaging.

Conclusions:

  • The hybrid MPI-CT scanner represents a significant advancement in multimodal imaging.
  • Simultaneous data acquisition enhances imaging efficiency and diagnostic potential.
  • This integrated system opens new avenues for research and clinical applications.