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Related Experiment Video

Updated: Jan 20, 2026

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Striatal dopamine transporter changes after glucose loading in humans.

Kyoungjune Pak1, Seongho Seo2,3, Keunyoung Kim1

  • 1Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Diabetes, Obesity & Metabolism
|September 4, 2019
PubMed
Summary

Glucose loading increases striatal dopamine transporter (DAT) availability in humans, correlating with body mass index (BMI). These findings suggest DAT

Keywords:
dopamine plasma membrane transport proteinsglucoseobesityreward

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Dopamine System

Background:

  • The dopamine transporter (DAT) regulates dopamine levels in the brain.
  • Understanding DAT's role in eating behavior is crucial for metabolic and addiction research.

Purpose of the Study:

  • To investigate the association between glucose loading, striatal DAT levels, and food intake in humans.
  • To explore the relationship between body mass index (BMI) and DAT availability after glucose intake.

Main Methods:

  • Positron Emission Tomography (PET) imaging using 18F-FP-CIT.
  • Intravenous glucose or placebo infusion in 33 healthy males.
  • Analysis of DAT binding potential (BPND) in striatal subregions (ventral striatum, caudate, putamen).

Main Results:

  • Glucose loading significantly increased DAT BPND in the ventral striatum, caudate nucleus, and putamen.
  • Increased DAT BPND in the ventral striatum after glucose loading negatively correlated with BMI.
  • No correlation between placebo-loaded DAT BPND and BMI was observed.

Conclusions:

  • Striatal DAT availability is modulated by glucose loading in humans.
  • BMI is associated with glucose-enhanced DAT availability, suggesting a link between dopamine signaling and weight regulation.
  • DAT may play a role in the reward pathways associated with eating behavior.