Association study between the polymorphisms of angiogenesis-related genes and cervical cancer susceptibility in...

Cervical cancer is the second most common malignant tumor in women, and its invasion and metastasis are regulated by tumor angiogenic growth factors and their cognate receptors. In this study, we explored the relationship between genetic polymorphisms of angiogenesis-related genes (VEGF-C, VEGFR-2, and VEGFR-3) and the risk of cervical cancer in Chinese Uygur population.

We investigated four single-nucleotide polymorphisms (SNPs) in 342 cervical cancer cases and 498 controls to evaluate their association with the risk of cervical cancer. Their correlations were evaluated by chi-squared test, Fisher's exact test, t test, and genetic model analyses. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression.

We observed that rs12646659 in VEGF-C was associated with a lower cervical cancer risk in allele, dominant, and log-additive models (allele: p = .017; dominant: p = .018; log-additive: p = .018). For the individuals older than 43, rs4604006 (VEGF-C) was related to an increased cervical cancer risk under codominant model (p = .035), and rs12646659 was significantly associated with a reduced cervical cancer risk in allele, dominant, log-additive models (allele: p = .028; codominant: p = .037; log-additive: p = .037) However, there were no significant correlation of rs1000611 (VEGFR-2) and rs1195571 (VEGFR-3) with cervical cancer risk in Chinese Uygur population.

Our study firstly provided evidence that rs4604006 and rs12646659 of VEGF-C gene were related to the susceptibility of cervical cancer in Chinese Uygur population.