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Updated: Jan 20, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction
Qian Wang1, Kumchok C Mgimpatsang1, Markella Konstantinidou1
1University of Groningen , Department of Drug Design , A. Deusinglaan 1 , 9713 AV Groningen , The Netherlands.
Abstract:
Easy to perform, functional group tolerant, and short syntheses of the privileged scaffold oxadiazole are highly desired. Here, a metal-free protocol for MCR-based synthesis of 2,5-disubstituted 1,3,4-oxadiazoles via a Ugi-tetrazole/Huisgen sequence was developed. Optimization and scope and limitations of this short and general sequence are described. The reaction was also successfully performed on a gram scale.
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