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Related Concept Videos

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder05:12

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Presented here is a protocol for the 2BC/CIE model of alcohol dependence in mice to study alcohol use disorder.
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The goal of the current protocol is to outline the steps necessary to establish and use a social preference assay for adult zebrafish and demonstrate that it can be used to characterize ethanol-induced social...
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The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders19:57

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Trace eyeblink classical conditioning (ECC) was used to assess hippocampal-dependent associative learning in adult rats that were administered a high concentration (11.9% v/v) of alcohol during early neonatal brain development. In general, ECC procedures are sound diagnostic tools for detecting brain dysfunction across many psychological and biomedical...
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Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis08:45

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This protocol describes a standard intermittent-access two-bottle choice home cage drinking paradigm to model alcohol consumption in rats. In addition, it provides step-by-step instructions to augment the standard protocol with a DIY lick detection system that enables microstructural analysis of drinking...
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Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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Oxidation of Alcohols02:37

Oxidation of Alcohols

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In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:
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Related Experiment Video

Updated: Jan 20, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

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Alcohol use disorders.

Andre F Carvalho1, Markus Heilig2, Augusto Perez3

  • 1Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Lancet (London, England)
|September 4, 2019
PubMed
Summary
This summary is machine-generated.

Alcohol use disorders are common mental health conditions that are undertreated due to stigma and lack of screening. Primary care should implement routine screening and interventions for alcohol use disorders.

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The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
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Area of Science:

  • Public Health
  • Mental Health
  • Addiction Medicine

Background:

  • Alcohol use disorders (AUDs) are prevalent global mental health conditions, particularly in high-income countries.
  • AUDs contribute significantly to mortality and disease burden, often linked to medical complications like liver cirrhosis.
  • Despite effective treatments, AUDs remain undertreated due to high stigma and insufficient primary care screening.

Purpose of the Study:

  • To highlight the prevalence and impact of alcohol use disorders.
  • To emphasize the need for improved screening and treatment within primary healthcare settings.
  • To advocate for integrated care strategies and supportive alcohol control policies.

Main Methods:

  • Review of the global prevalence and consequences of alcohol use disorders.
  • Analysis of barriers to treatment, including stigma and inadequate screening.
  • Discussion of existing effective psychosocial and pharmacological interventions.
  • Examination of the role of primary healthcare in managing AUDs.
  • Consideration of policy-level interventions for alcohol consumption reduction.

Main Results:

  • Alcohol use disorders are a major global health issue with significant mortality.
  • Stigma and lack of systematic screening in primary care impede treatment access.
  • Effective interventions, including brief advice and pharmacological treatments, are available.
  • Primary healthcare settings are crucial for routine screening and stepped care approaches.
  • Supportive alcohol control policies can reduce overall consumption and impact.

Conclusions:

  • Routine screening and intervention for alcohol use disorders in primary care are essential.
  • A multi-faceted approach combining clinical interventions with supportive policies is needed.
  • Addressing stigma and improving healthcare system integration can enhance AUD treatment outcomes.