[Problem of disease variability (pathomorphosis)]

The problem of pathomorphosis is analysed in case of infectious, infectious-allergic (rheumatism, glomerulonephritis) and neoplastic diseases. Pathomorphosis is considered as nosomorphosis in a broad (panorama of diseases) and narrow (particular disease) sense. Therefore the concepts of "general nosomorphosis" and "particular nosomorphosis" are introduced. The "specifics" of pathomorphosis of one or another disease (or a group of diseases) have been shown to be determined by epidemiologic and therapeutic factors. Pathomorphosis induced by a physician may become a process directed by him which is possible with the proper knowledge of not only epidemiological factors but also the mechanism of the drug effects, i. e. patho- and morphogenesis of pathomorphosis itself.