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Related Concept Videos

How to Culture, Record and Stimulate Neuronal Networks on Micro-electrode Arrays (MEAs)09:27

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Related Experiment Video

Updated: Jan 20, 2026

How to Culture, Record and Stimulate Neuronal Networks on Micro-electrode Arrays MEAs
09:27

How to Culture, Record and Stimulate Neuronal Networks on Micro-electrode Arrays MEAs

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The very large electrode array for retinal stimulation (VLARS)-A concept study.

Tibor Karl Lohmann1, Florent Haiss, Kim Schaffrath

  • 1Department of Ophthalmology, University Hospital RWTH Aachen, Aachen, Germany.

Journal of Neural Engineering
|September 4, 2019
PubMed
Summary
This summary is machine-generated.

A novel very large electrode array for retinal stimulation (VLARS) was safely implanted in rabbit eyes, demonstrating its capability to elicit visual cortex responses. This technology promises a wider visual field restoration for patients with retinal diseases.

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Area of Science:

  • Biomedical Engineering
  • Ophthalmology
  • Neuroscience

Background:

  • Degenerative retinal diseases cause blindness, necessitating innovative treatments.
  • Retinal implants offer vision restoration through electrical stimulation.
  • Current implants have limitations in visual field coverage.

Purpose of the Study:

  • To introduce and evaluate the safety and biocompatibility of a very large electrode array for retinal stimulation (VLARS).
  • To assess the acute stimulation capabilities of the VLARS device.
  • To determine the potential of VLARS for restoring a larger visual field.

Main Methods:

  • Developed a 12 mm diameter polyimide-based implant with 250 electrodes (VLARS).
  • Established implantation procedures in cadaveric porcine eyes.
  • Assessed biocompatibility in rabbits over 12 weeks via clinical exams, OCT, and histology.
  • Recorded cortical field potentials in rabbits during acute stimulation experiments.

Main Results:

  • VLARS implantation surgery was deemed safe but technically challenging.
  • Adverse events included retinal detachment (5/10 rabbits) and corneal edema (5/10 rabbits).
  • Acute stimulation successfully elicited cortical responses, confirming the array's functionality.

Conclusions:

  • Very large epiretinal arrays can be successfully implanted.
  • VLARS demonstrates the ability to evoke cortical responses.
  • VLARS technology holds potential for significantly expanding the restored visual field compared to existing implants.