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Updated: Aug 17, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
Non-A, non-B hepatitis-related hepatocellular carcinoma in a chimpanzee
E Muchmore1, H Popper, D A Peterson
1Laboratory for Experimental Medicine and Surgery in Primates (LEMSIP) New York University Medical Center, Tuxedo 10987.
Abstract:
Epidemiology has indicated the possible association of non-A, non-B hepatitis (NANBH) with hepatocellular carcinoma (HCC) in man, but there are no means for confirmation. Chimpanzees are recognized models for studying hepatitis B and NANBH, and may become carriers of both. The first case of HCC to be reported in chimpanzees was found after longitudinal study of a hepatitis B-free chimpanzee 7 years after inoculation with human plasma from a patient reported to have chronic NANBH.
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