Progress in Research on the Role of Flavonoids in Lung Cancer

Area of Science:

• Oncology
• Molecular Biology
• Pharmacology

Background:

• Lung cancer is a leading global cause of cancer mortality.
• There is a critical need for novel preventive and therapeutic strategies.
• Natural bioactive compounds, particularly flavonoids, show potential in lung cancer management.

Purpose of the Study:

• To review molecular mechanisms of natural compounds' anti-cancer effects in lung cancer.
• To focus on the role of flavonoids in regulating coding and non-coding genes.
• To examine the interplay between these compounds, oncogenes, tumor suppressor genes, microRNAs, and drug resistance.

Main Methods:

• Literature review of preclinical and clinical studies.
• Analysis of molecular pathways affected by natural compounds.
• Focus on gene regulation (coding and non-coding) and microRNAs.
• Evaluation of effects on oncogenes, tumor suppressor genes, and drug resistance.

Main Results:

• Flavonoids modulate molecular targets relevant to lung cancer.
• These compounds influence both coding and non-coding gene expression.
• Natural compounds show potential in regulating key oncogenes and tumor suppressor genes.
• Evidence suggests a role in overcoming drug resistance when combined with conventional therapy.

Conclusions:

• Natural bioactive compounds, especially flavonoids, offer promising avenues for lung cancer prevention and treatment.
• Understanding their molecular mechanisms, including gene and microRNA regulation, is crucial.
• Further research into their synergistic effects with conventional therapies is warranted to improve patient outcomes.