Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

32.4K
Bronchial thermoplasty is a non-drug procedure for severe persistent asthma that delivers thermal energy to the airway wall in a precisely controlled manner to reduce excessive airway smooth muscle. Reducing airway smooth muscle decreases the ability of the airways to constrict, thereby reducing the frequency of asthma...
32.4K
Acupuncture in a Rat Model of Asthma07:14

Acupuncture in a Rat Model of Asthma

6.5K
A high platform can fix rats without restriction and completely expose the acupoints on the back during acupuncture manipulation. This article describes methods for the fabrication of the high platform, establishes a rat model of asthma and measures changes in respiratory function using a noninvasive and real-time whole-body plethysmography (WBP)...
6.5K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

6.5K
Environmental allergens such as house dust mites (HDM) often contain microbial substances that activate innate immune responses to regulate allergic inflammation. The protocol presented here demonstrates the identification of dsRNA species in HDM allergens and characterization of their immunogenic activities in modulating eosinophilic lung...
6.5K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is Mediterranean diet associated with severe asthma control? A multi-center cross-sectional study in Greece.

The Journal of asthma : official journal of the Association for the Care of Asthma·2026
Same author

Clinical and Serological Characteristics of Idiopathic Inflammatory Myopathies According to the Presence of Interstitial Lung Disease and Initial Evaluating Medical Specialty: A Single-Center Experience.

Journal of personalized medicine·2026
Same author

The role of artificial intelligence in predicting COPD exacerbations using multimodal data: a systematic review.

ERJ open research·2026
Same author

Inhaler Adherence and Treatment Behaviors in COPD: A Study from Both Sides of the Aegean Sea.

Journal of aerosol medicine and pulmonary drug delivery·2026
Same author

Design of the MERCURION-IPF trial - intravenous immunoglobulin for the treatment of acute exacerbations of idiopathic pulmonary fibrosis.

Frontiers in immunology·2026
Same author

The Role of Cellular Senescence in Obstructive Airway Diseases: From Mechanisms to Therapeutic Targets.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Jan 20, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.4K

Severe Eosinophilic Asthma.

Agamemnon Bakakos1, Stelios Loukides1, Petros Bakakos2

  • 1Department of Respiratory Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Journal of Clinical Medicine
|September 5, 2019
PubMed
Summary
This summary is machine-generated.

Severe asthma involves eosinophilic inflammation, a key factor in T2-high inflammation. New biologic therapies targeting this inflammation significantly improve lung function and quality of life for patients with severe asthma.

Keywords:
anti-IL-5eosinophilinflammationinterleukin-4interleukin-5 (IL-5)severe asthma

More Related Videos

Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.5K
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.5K

Related Experiment Videos

Last Updated: Jan 20, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.4K
Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

6.5K
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.5K

Area of Science:

  • Pulmonology
  • Immunology
  • Pharmacology

Background:

  • Severe asthma significantly impacts patient quality of life, characterized by symptoms, exacerbations, and side effects.
  • Eosinophils, once overlooked, are now recognized as central to severe asthma's inflammatory processes.
  • T2-high inflammation, involving eosinophilic pathways, affects nearly half of severe asthma cases.

Purpose of the Study:

  • To review new insights into the pathogenesis of severe asthma, focusing on eosinophilic inflammation and T2-high pathways.
  • To summarize recent literature on the role of eosinophils in asthma inflammation, airway remodeling, and hypersensitivity.
  • To discuss advances in severe asthma management, particularly novel biologic therapies.

Main Methods:

  • Literature review of recent studies on severe asthma pathogenesis and treatment.
  • Analysis of the role of eosinophils and cytokines in T2-high inflammation.
  • Evaluation of the efficacy of targeted biologic therapies in severe eosinophilic asthma.

Main Results:

  • Eosinophilic inflammation and T2-high pathways are critical in severe asthma pathogenesis.
  • Recent literature highlights eosinophils' role in inflammation, airway remodeling, and hypersensitivity.
  • Targeted biologic therapies have substantially reduced exacerbations and improved lung function and quality of life.

Conclusions:

  • Understanding eosinophilic inflammation is key to managing severe asthma.
  • Novel monoclonal antibodies offer effective treatment options for severe eosinophilic asthma.
  • Personalized treatment selection is crucial for optimizing outcomes in severe asthma management.