Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors10:24

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

10.9K
This protocol describes a method for generating cortical interneuron progenitors and post-mitotic interneuron precursors from mouse embryonic stem cells using a modified embryoid body-to-monolayer method. These progenitors/precursors can be used in vitro or fluorescently sorted and transplanted into neonatal neocortex for studying fate determination, or used in therapeutic...
10.9K
Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI10:50

Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI

12.0K
Functional studies of the auditory system in mammals have traditionally been conducted using spatially-focused techniques such as electrophysiological recordings. The following protocol describes a method of visualizing large-scale patterns of evoked hemodynamic activity in the cat auditory cortex using functional magnetic resonance...
12.0K
Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

10.3K
Using two different transcranial magnetic stimulation (TMS) protocols, this manuscript describes how to measure and compare cortical inhibition within the primary motor cortex when adopting different attentional...
10.3K
Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

8.3K
Challenging young neurons in new brain regions can reveal important insights into how the environment sculpts neuronal fate and maturation. This protocol describes a procedure to harvest interneuron precursors from specific brain regions and transplant them either homotopically or heterotopically into the brain of postnatal...
8.3K
Measuring Cerebral Blood Volume in the Auditory Cortex Using Vascular Space Occupancy01:21

Measuring Cerebral Blood Volume in the Auditory Cortex Using Vascular Space Occupancy

161
Position a human participant’s head within the head coil of a functional magnetic resonance imaging, or fMRI, system.Employ vascular space occupancy or VASO, a technique to measure changes in cerebral blood volume, or CBV, the blood volume within the brain.Begin by applying an inversion recovery pulse to suppress signals from blood, allowing only signals from the surrounding tissue within the region to be detected.Next, use MRI-compatible earbuds to deliver auditory stimuli.The stimuli...
161
Transplantation of Interneuron Precursor Cells into the Brain of a Mouse Pup03:26

Transplantation of Interneuron Precursor Cells into the Brain of a Mouse Pup

322
Source: Quattrocolo, G., et al. Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains. J. Vis. Exp. (2018)This video demonstrates the transplantation of interneuron precursor cells into the neonatal mouse brain using either a homotopic or heterotopic approach. The procedure involves securing an anesthetized recipient pup, identifying the target brain region, and injecting a suspension of precursor cells derived from a donor pup at the same developmental stage.
322

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Anesthetic Depth Using the Bispectral Index During Sleep Endoscopy With PAP Titration.

The Laryngoscope·2026
Same author

Survey of Hippocampal Responses to Sound in Naive Mice Reveals Widespread Activation by Broadband Noise Onsets.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

A Comparison of Brow Elevation and Complications: Endoscopic Versus Pretrichial Brow Lift.

The Laryngoscope·2025
Same author

Comparing Transoral Robotic Surgery and Hypoglossal Nerve Stimulation Using Mean Disease Alleviation in OSA.

The Annals of otology, rhinology, and laryngology·2025
Same author

Anthropometric Predictors in Drug-Induced Sleep Endoscopy With Positive Airway Pressure.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2025
Same author

Impact of socioeconomic disparities on CPAP adherence.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2025
Same journal

Translational profiling of Drd2-expressing populations reveals molecular heterogeneity of dentate gyrus mossy cells along the dorsoventral axis.

eNeuro·2026
Same journal

Movement Disorder Patients with Depression have Altered Corticostriatal Alpha-Beta Power Response to Reward and Loss.

eNeuro·2026
Same journal

Ocular speech tracking persists in blindness, but its dynamics and oculo-cerebral connectivity depend on visual status.

eNeuro·2026
Same journal

Emergent multidien cycles from partial circadian synchrony.

eNeuro·2026
Same journal

Adolescent social isolation induces persistent impairments in emotional discrimination and helping behavior.

eNeuro·2026
Same journal

Increased Ih Current Is Associated with Reduced Hippocampal CA1 Excitability in a Mouse Model of Multiple Sclerosis.

eNeuro·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors
10:24

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

10.9K

Movement and VIP Interneuron Activation Differentially Modulate Encoding in Mouse Auditory Cortex.

James Bigelow1,2, Ryan J Morrill1,3,2, Jefferson Dekloe1,2

  • 1Coleman Memorial Laboratory, University of California, San Francisco, San Francisco, California 94143.

Eneuro
|September 5, 2019
PubMed
Summary
This summary is machine-generated.

Movement and vasoactive intestinal peptide (VIP) neuron activation differently impact auditory cortex function. While VIP activation boosts firing rates, movement and VIP activation together do not improve information transfer during auditory processing in mice.

Keywords:
informationinterneuronslocomotionoptogeneticsvasoactive intestinal peptide

More Related Videos

Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI
10:50

Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI

Published on: February 19, 2014

12.0K
Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

10.3K

Related Experiment Videos

Last Updated: Jan 20, 2026

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors
10:24

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

10.9K
Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI
10:50

Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI

Published on: February 19, 2014

12.0K
Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

10.3K

Area of Science:

  • Neuroscience
  • Auditory Cortex Research
  • Sensory Information Processing

Background:

  • Information processing in sensory cortex is influenced by factors like arousal and movement.
  • Movement in visual cortex enhances neural responses via a VIP-expressing disinhibitory circuit.
  • Auditory cortex shows reduced spiking during movement, contrasting with visual cortex findings.

Purpose of the Study:

  • To investigate the effects of movement and VIP interneuron activation on auditory cortex responses.
  • To determine if movement-induced changes in spike rates alter stimulus-response mutual information in the auditory cortex.
  • To analyze the independent and combined effects of movement and VIP activation on auditory information processing.

Main Methods:

  • Examined auditory cortex responses to tone cloud stimuli in awake mice.
  • Compared neural activity during spontaneous movement versus still conditions.
  • Used optogenetics to activate VIP+ cells, analyzing movement and VIP activation effects separately and together.

Main Results:

  • Movement decreased stimulus-related spike rates, mutual information, and encoding efficiency in the auditory cortex.
  • VIP interneuron activation increased stimulus-evoked spike rates but did not enhance mutual information, reducing encoding efficiency.
  • Combined movement and VIP activation restored spike rates but not information transfer.

Conclusions:

  • Movement and VIP activation have distinct, partially interacting effects on auditory cortex function.
  • The disinhibitory circuit's role in the auditory cortex differs from the visual cortex regarding information processing during movement.
  • Movement-induced deficits in auditory information transfer are not fully rescued by VIP interneuron activation.