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Related Experiment Video

Updated: Jan 20, 2026

Generation of Human Microglia to Combine Them with Retinal Organoids for Improved Disease Modeling

Generation of Human Microglia to Combine Them with Retinal Organoids for Improved Disease Modeling

Published on: July 26, 2024

Microglia in Retinal Degeneration.

Khalid Rashid¹, Isha Akhtar-Schaefer¹, Thomas Langmann^1,2

¹Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Frontiers in Immunology

|September 5, 2019

Summary

This summary is machine-generated.

Microglia cells protect the retina but can worsen disease when chronically activated. This review examines microglial roles in retinal pathologies and discusses therapies to modulate immune responses for better outcomes.

Keywords:

chronic inflammation immunomodulation microglia neuroprotection retina

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Last Updated: Jan 20, 2026

Generation of Human Microglia to Combine Them with Retinal Organoids for Improved Disease Modeling

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In Vivo Imaging of Retinal Microglia in a Mouse Model of Glaucoma

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Methylnitrosourea MNU-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics

Methylnitrosourea MNU-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics

Published on: October 20, 2014

Area of Science:

Ophthalmology
Neuroscience
Immunology

Background:

The retina's ordered structure is sensitive to damage.
Microglia, the resident immune cells, protect the retina from acute injury.
Chronic inflammation driven by microglia can exacerbate retinal diseases.

Purpose of the Study:

To review microglial responses in retinal pathologies.
To explore the role of sustained microglial activation in disease.
To discuss immunomodulatory therapies for retinal diseases.

Main Methods:

Literature review of recent studies.
Analysis of microglial behavior in various retinal diseases.
Discussion of therapeutic strategies targeting immune responses.

Main Results:

Microglia exhibit dual roles in retinal pathologies, offering protection or causing damage.
Sustained pathological stimuli lead to dysregulated microglial inflammatory responses.
Diverse retinal pathologies involve chronic immune reactions and degeneration.

Conclusions:

Understanding microglial dysregulation is crucial for treating retinal diseases.
Immunomodulatory therapies offer potential for improving disease outcomes.
Targeting microglial responses may mitigate retinal degeneration.