HIV and Solid Organ Transplantation: Where Are we Now

Area of Science:

• Transplantation immunology
• Infectious disease management
• Organ donation and procurement

Background:

• Review of 30 years of HIV and solid organ transplantation evolution.
• Focus on recent breakthroughs enabling transplantation from HIV-infected to HIV-uninfected individuals.

Purpose of the Study:

• To highlight the international progress in HIV and solid organ transplantation.
• To emphasize the implications of recent developments in HIV-positive to HIV-negative organ transplantation.

Main Methods:

• Review of scientific literature and clinical case studies.
• Analysis of advancements in donor eligibility and recipient outcomes.

Main Results:

• Successful partial liver transplant from an HIV-infected mother to an HIV-uninfected child in 2017.
• HIV-infected individuals on combination antiretroviral therapy (cART) are viable living organ donors.
• HIV-positive-to-HIV-negative organ transplantation is a new therapeutic reality.

Conclusions:

• HIV-infected individuals on cART represent an underutilized donor pool.
• HIV-positive-to-HIV-negative transplantation offers novel solutions for critical organ shortages.
• This approach expands therapeutic options for patients awaiting organ transplants.