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Updated: Jan 20, 2026

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
Published on: March 24, 2023
Natural orifice specimen extraction (NOSE) surgery with rectal eversion and total extra-abdominal resection
S K Efetov1, I A Tulina2, V D Kim2
1Clinic of Colorectal and Minimally Invasive Surgery, I.M. Sechenov First Moscow State Medical University (Sechenov University), 2-4 Bolshaya Pirogovskaya st., Moscow, 119991, Russia. efetov@mail.ru.
This study introduces a novel transanal Natural Orifice Specimen Extraction (NOSE) technique for colorectal surgery. The variation proved safe and effective, showing good patient outcomes and low complication rates.
Area of Science:
- Colorectal Surgery
- Minimally Invasive Surgery
- Surgical Innovation
Background:
- Natural orifice specimen extraction (NOSE) surgery is increasingly adopted by colorectal surgeons.
- Technical variations in NOSE procedures are actively being explored and debated.
- Standardization of techniques remains a challenge in the evolution of NOSE surgery.
Purpose of the Study:
- To present and evaluate a novel variation of transanal NOSE following laparoscopic or robotic total mesorectal excision (TME).
- To demonstrate the technical feasibility of rectal eversion for extracorporeal specimen retrieval.
- To assess the safety and efficacy of this NOSE technique using patient-reported outcome measures.
Main Methods:
- A new transanal NOSE technique involving rectal eversion using a specialized rod after laparoscopic/robotic TME was developed.
- Rectal eversion facilitates extracorporeal resection and anvil placement.
- Patient outcomes were assessed using the Clinical Patient Grading Assessment Scale and Low Anterior Resection Syndrome (LARS) score.
Main Results:
- Seven female patients with rectal cancer underwent the procedure (5 laparoscopic, 2 robotic TME) without intraoperative or postoperative complications.
- One month post-stoma closure, the median Clinical Patient Grading Assessment Scale indicated significant improvement ('a good deal better').
- Median LARS scores showed a trend towards improvement postoperatively compared to preoperative scores.
Conclusions:
- This specific variation of transanal NOSE surgery, incorporating rectal eversion, is safe and effective.
- The technique offers a viable option for specimen extraction in selected rectal cancer patients.
- Further research may validate this approach in larger patient cohorts.
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