Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Palladium-Catalyzed Cross Coupling06:19

Palladium-Catalyzed Cross Coupling

36.2K
Source: Vy M. Dong and Faben Cruz, Department of Chemistry, University of California, Irvine, CA
This experiment will demonstrate the concept of a palladium-catalyzed cross coupling. The set-up of a typical Pd-catalyzed cross coupling reaction will be illustrated. Pd-catalyzed cross coupling reactions have had a profound effect on how synthetic chemists create molecules. These reactions have enabled chemists to construct bonds in new and more efficient ways. Such reactions have found widespread...
36.2K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions

25.9K
Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium [(P(NC5H10)3)2Pd(Cl)2] (1) is an easy accessible, cheap, and air stable, but highly active Heck catalyst with an excellent functional group tolerance that efficiently operates under mild reaction conditions to give the coupling products in very high...
25.9K
Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination11:16

Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination

5.9K
Presented here is a protocol for the synthesis of silver-palladium (Ag-Pd) alloy nanoparticles (NPs) supported on ZrO2 (Ag-Pd/ZrO2). This system allows for harvesting energy from visible light irradiation to accelerate and control molecular transformations. This is illustrated by nitrobenzene reduction under light irradiation catalyzed by Ag-Pd/ZrO2...
5.9K
Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles11:54

Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles

10.7K
The main goal of this work is to elucidate the role of capping agents in regulating the size of palladium nanoparticles by combining in situ small angle x-ray scattering (SAXS) and ligand-based kinetic...
10.7K
Synthesis Method for Cellulose Nanofiber Biotemplated Palladium Composite Aerogels11:27

Synthesis Method for Cellulose Nanofiber Biotemplated Palladium Composite Aerogels

8.7K
A synthesis method for cellulose nanofiber biotemplated palladium composite aerogels is presented.The resulting composite aerogel materials offer potential for catalysis, sensing, and hydrogen gas storage...
8.7K
Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

10.2K
Detailed and generalized protocols are presented for the synthesis and subsequent purification of four palladium N-heterocyclic carbene complexes from benzimidazolium salts. The complexes were tested for catalytic activity in arylation and Suzuki-Miyaura reactions. For each reaction investigated, at least one of the four complexes successfully catalyzed the...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A General Approach to <i>geminal</i>-Dimethyl <i>trans</i>-Decalin Terpenoids.

Journal of the American Chemical Society·2026
Same author

A Unified Approach for the Synthesis of Conformationally Locked and sp<sup>2</sup>-sp<sup>3</sup> Fused Hybrids.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Atomically Dispersed Iron-Catalyzed Aerobic Hydroxylation of Allylic and Propargylic C─H Bonds.

Angewandte Chemie (International ed. in English)·2026
Same author

Stereodivergent Construction of <i>trans</i>-Decalin-Based Terpenoids.

Journal of the American Chemical Society·2026
Same author

Chemoselective 1,2-Sulfonamidoazidation of Styrene via Single-Atom-Site Cobalt Catalysis.

Journal of the American Chemical Society·2026
Same author

Harnessing Photoenzymatic Systems for Intermolecular C-H Fluorination.

Angewandte Chemie (International ed. in English)·2025

Related Experiment Video

Updated: Jan 20, 2026

Palladium-Catalyzed Cross Coupling; Heck Coupling Reaction
06:19

Palladium-Catalyzed Cross Coupling; Heck Coupling Reaction

Published on: April 30, 2023

36.2K

Palladium-Catalyzed Dearomative syn-1,4-Oxyamination.

Conghui Tang1, Mikiko Okumura1, Hejun Deng1

  • 1Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, IL 61801, USA.

Angewandte Chemie (International Ed. in English)
|September 5, 2019
PubMed
Summary

A new palladium-catalyzed reaction enables dearomative syn-1,4-oxyamination of arenes. This method provides efficient access to complex molecules and functionalized small molecules from simple starting materials.

Keywords:
arenearenophiledearomatizationoxyaminationphotochemistry

More Related Videos

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.9K
Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination
11:16

Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination

Published on: August 18, 2020

5.9K

Related Experiment Videos

Last Updated: Jan 20, 2026

Palladium-Catalyzed Cross Coupling; Heck Coupling Reaction
06:19

Palladium-Catalyzed Cross Coupling; Heck Coupling Reaction

Published on: April 30, 2023

36.2K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.9K
Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination
11:16

Preparation of Silver-Palladium Alloyed Nanoparticles for Plasmonic Catalysis under Visible-Light Illumination

Published on: August 18, 2020

5.9K

Area of Science:

  • Organic Chemistry
  • Catalysis
  • Synthetic Methodology

Background:

  • Dearomatization reactions offer pathways to complex molecular architectures.
  • Developing catalytic methods for functionalizing non-activated arenes remains a significant challenge in organic synthesis.

Purpose of the Study:

  • To develop a novel palladium-catalyzed dearomative syn-1,4-oxyamination protocol.
  • To enable the synthesis of functionalized arenes using readily available starting materials.

Main Methods:

  • A one-pot palladium-catalyzed reaction employing arenophile chemistry.
  • Formal allylic substitution of para-cycloadducts with oxygen nucleophiles.
  • Asymmetric catalysis for enantioselective synthesis.

Main Results:

  • Successful development of a syn-1,4-oxyamination protocol for non-activated arenes.
  • Demonstrated compatibility with various arenes and O-nucleophiles (oximes, benzyl alcohols).
  • Achieved high enantioselectivity in the asymmetric variant.

Conclusions:

  • The developed dearomative functionalization provides rapid and controlled access to molecular complexity.
  • The resulting dearomatized products are versatile intermediates for further derivatization.
  • This method offers a straightforward route to functionalized small molecules from simple arenes.