Related Experiment Video
Updated: Jan 20, 2026
Palladium-Catalyzed Cross Coupling; Heck Coupling Reaction
Published on: April 30, 2023
Elaborating Complex Heteroaryl-Containing Cycles via Enantioselective Palladium-Catalyzed Cycloadditions
Barry M Trost1, Zhiwei Jiao1, Chao-I Joey Hung1
1Department of Chemistry, Stanford University, Stanford, CA, 94305-5080, USA.
Abstract:
A general method for asymmetric synthesis of heteroaryl-containing cycles via palladium-catalyzed cyclization is reported. Most classes of nitrogen-containing aromatics, including pyridines, quinolines, pyrimidines, various azoles and the derivatives of nucleobases are compatible substrates, offering various heteroaryl-substituted cyclopentane, pyrrolidine, furanidine and bicyclo[4.3.1]decadiene derivatives with good to excellent enantioselectivity and diastereoselectivity.
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