Two Hands Grip Better Than One for Tight Binding and Specificity: How a Phage Endolysin Fits into the Cell Wall of
Matthias Buck1, Thomas Gerken2
1Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, OH 44106, USA; Department of Neurosciences, Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, OH 44106, USA; Department of Pharmacology, Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, OH 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, OH 44106, USA.
Abstract:
Endolysin enzymes of bacteriophages that cut up cell walls have a potential use in combating bacterial antibiotic resistance. In this issue of Structure, Lee et al. (2019) present tandem SH3b domains as the structural basis of an endolysin against Bacillus cereus that selectively recognize opposing glycan strands of the bacterial cell wall peptidoglycan.
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