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Theophylline antagonizes the effect of diazepam on ventricular automaticity
F Ruiz1, J Hernández, J A Ribeiro
1Department of Pharmacology, University of Murcia Medical School, Spain.
European Journal of Pharmacology
|October 18, 1988
Abstract:
The effect of diazepam on ventricular automaticity induced by a local injury was investigated in the isolated right ventricle of the rat in the presence of the diazepam central antagonist, RO 15-1788, and of the adenosine antagonist, theophylline. Theophylline but not RO 15-1788 antagonized the inhibitory effect induced by diazepam on ventricular automaticity. The inhibitory effect of adenosine but not that of 2-chloroadenosine was potentiated in the presence of diazepam. The results suggest that the inhibitory effect of diazepam on ventricular automaticity results from the inhibition of adenosine uptake.