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Updated: Jan 20, 2026
Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
Association between ACYP2 polymorphisms and the risk of renal cell cancer
Yuhe Wang1,2, Yongtong Zhang3, Yao Sun4
1Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Background:
Kidney cancer is the predominant form of malignancy of the kidney and accounts for approximately 3%-4% of all cancers. Renal cell cancer (RCC) represents more than 85% of kidney cancer. It has been reported that genetic factors may predispose individuals to RCC. This study evaluated the association between Acylphosphatase 2 (ACYP2) gene polymorphisms and RCC risk in the Han Chinese population.
Methods:
Twelve single-nucleotide polymorphisms (SNPs) in ACYP2 were genotyped using the Agena MassARRAY platform from 293 RCC patients and 495 controls. The Chi-squared test, genetic models, haplotype, and stratification analyses were used to evaluate the association between SNPs and the risk of RCC. The relative risk was estimated using the odds ratio (OR) and 95% confidence interval (CI).
Results:
We observed that the rs6713088 allele G (OR = 1.26, 95% CI: 1.03-1.53, p = .023) and rs843711 allele T (OR = 1.29, 95% CI: 1.06-1.57, p = .010) were associated with increased RCC risk. Genetic model analyses found that rs843711 was significantly associated with an increased RCC risk under the recessive model and log-additive model after adjusting for age and gender. Haplotype analysis showed that the haplotype "TTCTCGCC" (OR = 0.67, 95% CI: 0.48-0.94, p = .021) was associated with a decreased risk of RCC in the Han Chinese population. Stratification analysis also found that rs6713088 and rs843711 were significantly associated with increased RCC risk.
Conclusion:
In summary, the results suggested that ACYP2 polymorphisms could be used as a genetic marker for RCC. Additional functional and association studies are required to validate our results.
Insights
Genetic variations in the Acylphosphatase 2 (ACYP2) gene, specifically rs6713088 and rs843711, are linked to an increased risk of renal cell cancer (RCC) in the Han Chinese population. Certain ACYP2 polymorphisms may serve as valuable genetic markers for kidney cancer susceptibility.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Kidney cancer, primarily renal cell cancer (RCC), accounts for 3-4% of all cancers.
- Genetic predisposition is implicated in the development of RCC.
- This study investigates the link between ACYP2 gene polymorphisms and RCC risk.
Purpose of the Study:
- To evaluate the association between specific single-nucleotide polymorphisms (SNPs) in the ACYP2 gene and the risk of developing RCC.
- To identify potential genetic markers for RCC susceptibility in the Han Chinese population.
Main Methods:
- Genotyping of twelve ACYP2 SNPs in 293 RCC patients and 495 controls using Agena MassARRAY.
- Statistical analyses including Chi-squared tests, genetic models, haplotype analysis, and stratification analysis.
- Estimation of relative risk using odds ratios (OR) and 95% confidence intervals (CI).
Main Results:
- The rs6713088 allele G (OR=1.26) and rs843711 allele T (OR=1.29) were associated with increased RCC risk.
- rs843711 showed significant association with increased RCC risk under recessive and log-additive models.
- A specific haplotype (TTCTCGCC) was associated with decreased RCC risk (OR=0.67).
Conclusions:
- ACYP2 gene polymorphisms may serve as potential genetic markers for RCC risk.
- Further functional and association studies are warranted to validate these findings.
- The study highlights the role of genetic factors in RCC development within the Han Chinese population.
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