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Updated: Jan 20, 2026

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The Microbiome and Aging.

Bianca Bana1, Filipe Cabreiro2,3

  • 1Institute of Structural and Molecular Biology, University College London and Birkbeck, University of London, London WC1E 6BT, United Kingdom.

Annual Review of Genetics
|September 6, 2019
PubMed
Summary
This summary is machine-generated.

Aging involves host-microbiota interactions, not just the host alone. Changes in the microbiome and its relationship with bacteria influence aging and lifespan, suggesting microbiome dysbiosis as an aging biomarker.

Keywords:
agingcaloric restrictionhologenomeinflammationlife spanmicrobiome

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Area of Science:

  • Gerontology and Microbiology
  • Host-Microbiome Interactions
  • Aging Biology

Background:

  • Aging is a complex process linked to organismal decay and disease.
  • Current research predominantly focuses on host-intrinsic aging mechanisms.
  • The host microbiota significantly impacts host health and metabolism.

Purpose of the Study:

  • To explore the aging process as a function of host-microbiota interplay.
  • To review how microbial communities change during host aging.
  • To investigate the impact of host-bacterial interactions on organismal lifespan.

Main Methods:

  • Literature review focusing on aging and the microbiome.
  • Analysis of host-microbiota interactions in aging.
  • Examination of experimental animal models for aging research.

Main Results:

  • Microbiota composition and function evolve with host aging.
  • Host-microbiota genetic interplay influences aging phenotypes and lifespan.
  • Microbiome dysbiosis emerges as a potential hallmark and biomarker of aging.

Conclusions:

  • Viewing the host and microbiota as a single aging entity is crucial.
  • Microbiota-dependent mechanisms are key regulators of aging.
  • Microbiome dysbiosis represents a novel aging biomarker.