Related Experiment Video

Updated: Jan 20, 2026

Stress Response and Hypothalamic-Pituitary Axis
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Association between BDNF Polymorphism and Hypothalamic-Pituitary-Adrenal Activity in Later Adulthood

Alexandra J Fiocco1, Danielle D'Amico2, Louis de Beaumont3

  • 1Institute for Stress and Wellbeing Research, Ryerson University, Toronto, Ontario, Canada, afiocco@psych.ryerson.ca.

Gerontology
|September 6, 2019
PubMed
Summary

The brain-derived neurotrophic factor (BDNF) Met+ genotype is linked to reduced cortisol reactivity in older adults. This finding suggests BDNF may influence stress responses in aging populations.

Keywords:
Brain-derived neurotrophic factorDiurnal cortisolOlder adultsStress reactivityTrier social stress testVal66Met BDNF gene

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