Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Myocardial Infarction in Rats07:45

Acute Myocardial Infarction in Rats

54.5K
The rat model of acute myocardial infarction (AMI) is useful to study the consequence of a MI on cardiac pathophysiological and physiological...
54.5K
Noninvasive, High-throughput Determination of Sleep Duration in Rodents07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

8.2K
We describe a high-throughput method of measuring sleep by means of activity-based home-cage monitoring. This method offers advantages over traditional EEG-based methods. It is well validated for the determination of total sleep duration and can be a powerful tool to monitor sleep in rodent models of human...
8.2K
LAD-Ligation: A Murine Model of Myocardial Infarction08:23

LAD-Ligation: A Murine Model of Myocardial Infarction

45.9K
This video demonstrates how to use a fast and reliable model to study pathobiological and pathophysiological processes of myocardial...
45.9K
Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

28.6K
This protocol describes the porcine myocardial infarction (MI) model using a 90 min closed-chest coronary balloon occlusion of the left anterior descending artery (LAD), followed by reperfusion. Furthermore, the protocol for several outcome parameters, such as cardiac function, hemodynamics, microvascular resistance, and infarct size, are also...
28.6K
A Cryoinjury Model to Study Myocardial Infarction in the Mouse06:29

A Cryoinjury Model to Study Myocardial Infarction in the Mouse

10.0K
This article demonstrates a model to study cardiac remodeling after myocardial cryoinjury in...
10.0K
Histological Quantification of Chronic Myocardial Infarct in Rats09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

15.4K
The post-mortem assessment of myocardial infarction (MI) in rodents is based on quantification of the infarct on stained heart sections. We describe an accurate method to quantify the infarct size using systematic sampling of harvested rat hearts from base to apex and image analyses of trichrome-stained histological sections.
15.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A data-driven trajectory analysis reveals associations between temporal patterns of within-day energy intake and mortality risk in U.S. adults: NHANES 2005-2018.

European journal of nutrition·2026
Same author

Sleep patterns and glycemia in adults with cystic fibrosis-related diabetes: a remote pilot study.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

Rare Coding Variants Reveal Distinct Genetic Architectures Across Multidimensional Sleep Phenotypes.

medRxiv : the preprint server for health sciences·2026
Same author

Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.

Diabetes care·2026
Same author

Obesity Polygenic Risk and Healthy Lifestyle Interactions on Weight Trajectories in Women and Men.

Journal of the American Heart Association·2026
Same author

A Common <i>CD36</i> Variant and the Genetic Landscape of Dilated Cardiomyopathy in Individuals of African Ancestry.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jan 20, 2026

Acute Myocardial Infarction in Rats
07:45

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

54.5K

Sleep Duration and Myocardial Infarction.

Iyas Daghlas1, Hassan S Dashti1, Jacqueline Lane2

  • 1Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Journal of the American College of Cardiology
|September 7, 2019
PubMed
Summary

Short sleep duration is a causal risk factor for myocardial infarction (MI). Healthy sleep duration may mitigate genetic predisposition to coronary artery disease, suggesting sleep extension could prevent MI.

Keywords:
Mendelian randomizationUK Biobankcoronary artery diseasegenetic risk scoremyocardial infarctionsleep duration

More Related Videos

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

8.2K
LAD-Ligation: A Murine Model of Myocardial Infarction
08:23

LAD-Ligation: A Murine Model of Myocardial Infarction

Published on: October 14, 2009

45.9K

Related Experiment Videos

Last Updated: Jan 20, 2026

Acute Myocardial Infarction in Rats
07:45

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

54.5K
Noninvasive, High-throughput Determination of Sleep Duration in Rodents
07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

8.2K
LAD-Ligation: A Murine Model of Myocardial Infarction
08:23

LAD-Ligation: A Murine Model of Myocardial Infarction

Published on: October 14, 2009

45.9K

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Genetics

Background:

  • Observational studies link extreme sleep durations to myocardial infarction (MI).
  • The causal role of sleep in MI and its interaction with genetic risk for coronary disease remain unclear.

Purpose of the Study:

  • Investigate associations between sleep duration and incident MI.
  • Assess causality using Mendelian randomization (MR).
  • Examine joint effects with sleep traits and genetic risk.

Main Methods:

  • Utilized UK Biobank data from 461,347 participants.
  • Estimated MI risk for short (<6h) and long (>9h) sleep durations.
  • Conducted 2-sample MR for sleep duration and MI, with UK Biobank replication.

Main Results:

  • Short sleepers had 20% higher MI risk; long sleepers had 34% higher risk.
  • Healthy sleep duration (6-9h) mitigated MI risk, even with high genetic liability.
  • MR analyses supported a causal effect of short sleep duration on MI.

Conclusions:

  • Short sleep duration is a potential causal risk factor for MI.
  • Healthy sleep duration may counteract genetic predisposition to coronary artery disease.
  • Further research into sleep extension for MI prevention is warranted.