Toll-like receptor 3 deficiency in autoimmune encephalitis post-herpes simplex encephalitis

Thaís Armangue1, Benjamin J Baucells2, Alexandru Vlagea2

  • 1From the Neuroimmunology Program (T.A., M.P.-P., J.D.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Pediatric Neuroimmunology Unit (T.A.), Neurology Department, Sant Joan de Déu (SJD) Children's Hospital, University of Barcelona, Barcelona, Spain; Clinical Immunology and Primary Immunodeficiencies Unit (B.J.B., A.D.-M., L.A., A.E.-S.), Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Universitat de Barcelona, Spain; Clinical Immunology Unit (A.V., A.E.-S., R.R.-G., M.J., L.A.), Hospital Sant Joan de Déu-Hospital Clínic Barcelona, Barcelona, Spain; Laboratory of Immunogenetics of Human Diseases (R.P.d.D.), IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain; Innate Immunity Group (R.P.d.D.), IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain; Interdepartmental Group of Immunodeficiencies (R.P.d.D.), Madrid, Spain; Neurology Department (J.D.), University of Pennsylvania, Philadelphia; and Catalan Institute for Research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain. tarmangue@sjdhospitalbarcelona.org lalsina@sjdhospitalbarcelona.org.

Abstract

No abstract available in PubMed .

Related Concept Videos

Plaquing of Herpes Simplex Viruses04:41

Plaquing of Herpes Simplex Viruses

Plaquing is a routine method used to quantify live viruses in a population. Though plaquing is frequently taught in various microbiology curricula with bacteria and bacteriophages, plaquing of mammalian viruses is more complex and time-consuming. This protocol describes the procedures that function reliably for regular work with herpes simplex...
6.9K
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Here, we present a protocol for creating an immunocompetent ICR (Institute of Cancer Research) murine model of central nervous system infection to display the development of neuropathy. Monitoring acute viral encephalitic disorders by identical disease scores could be performed for showing dengue virus-induced neuropathy in...
7.1K
Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus06:14

Growth, Purification, and Titration of Oncolytic Herpes Simplex Virus

In this manuscript, we describe a simple method of growth, purification, and titration of the oncolytic herpes simplex virus for preclinical use.
7.4K
Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 111:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

The skin is one target tissue of the human pathogen herpes simplex virus type 1 (HSV-1). To explore the invasion route of HSV-1 into tissue, we established an ex vivo infection model of murine epidermal sheets which represent the outermost layer of...
11.6K
The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials08:36

The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials

Here, we present a protocol to analyze the effectiveness and safety of Angong Niuhuang Pill in the treatment of viral...
1.1K
Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis08:20

Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis

Autoimmune encephalitis is a new category of antibody-mediated diseases of the central nervous system. Hippocampal neurons can be used to discover and characterize these antibodies. This article provides a protocol for primary cell culture and immunostaining to determine autoantibodies in the serum and cerebrospinal fluid of...
3.8K