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Updated: Jan 20, 2026
A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
Published on: April 26, 2015
Resuscitation outcomes of infants that do not achieve a 5 min target SpO2 saturation
Anup C Katheria1, Kasim Hassen2, Wade Rich2
1Neonatal Research Institute at Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA, USA. anup.katheria@sharp.com.
Objective:
To determine differences in the duration and level of resuscitation between infants that achieve a peripheral oxygen saturation (SpO2) of 80% by 5 min compared with those who remain below 80% saturation.
Study Design:
Infants < 32 weeks GA were analyzed. Pulse rate, SpO2, airway pressure, and fraction of inspired oxygen were collected during the first 10 min of life.
Results:
Two hundred and eighty-four infants were analyzed of which 100 had SpO2 < 80% at 5 min of life. Composite outcome of death and any IVH was greater in the <80% at 5 min group. These infants had lower heart rates and lower SpO2 despite increased mean airway pressure and higher FiO2 (p < 0.001).
Conclusion:
Infants <32 weeks GA that do not achieve a peripheral arterial saturation of 80% by 5 min of life experience more death or severe IVH. This association is amongst the strongest seen of any predictor of morbidity in the delivery room.
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