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Effects of 100% oxygen during deferred cord clamping on oxidative stress markers: a sub-study of a randomized

Anup C Katheria1, Satyan Lakshminrusimha2, Ana Morales3

  • 1Neonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, USA. anup.katheria@sharp.com.

Pediatric Research
|June 22, 2026
PubMed

Insights

This study found no significant difference in oxidative stress markers between premature infants receiving 100% or 30% oxygen during deferred cord clamping (DCC). Further research is needed to clarify redox effects in neonatal resuscitation.

Area of Science:

  • Neonatal physiology and oxidative stress research.
  • Biomarker analysis in premature infants.

Background:

  • Premature infants are vulnerable to oxidative stress.
  • Deferred cord clamping (DCC) is a common practice in neonatal care.
  • Oxygen administration during DCC may influence oxidative changes.

Purpose of the Study:

  • To evaluate oxidative changes in premature infants receiving 100% oxygen versus 30% oxygen during DCC.
  • To compare reduced-to-oxidized glutathione (GSH/GSSG) ratios between oxygen groups.

Main Methods:

  • Premature infants (220/7-286/7 weeks) received DCC with either 30% or 100% oxygen.
  • Blood samples were collected from umbilical segments and postnatal lines.
  • GSH/GSSG ratios were analyzed using liquid chromatography-tandem mass spectrometry.

Main Results:

  • No statistically significant differences in GSH/GSSG ratios were observed between the 100% and 30% oxygen groups in arterial cord blood, venous cord blood, or postnatal samples.
  • Gestational age was similar between groups (median 264/7 weeks).

Conclusions:

  • Brief oxygen administration (30% vs. 100%) during DCC did not show significant differences in GSH/GSSG ratios.
  • Redox effects remain unclear due to high variability and limited statistical power.
  • Further studies are required to understand oxidative damage during neonatal resuscitation and DCC.
Abstract

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