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Recent progress in copper nanocluster-based fluorescent probing: a review.

Taiping Qing1, Kaiwu Zhang2, Zhihe Qing3

  • 1College of Environment and Resources, Xiangtan University, Xiangtan, 411105, Hunan Province, China. taiping_qing@163.com.

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Copper nanoclusters (CuNCs) offer efficient, low-cost synthesis and tunable fluorescence for biochemical sensing. This review highlights their progress in assays for biomolecules and environmental analyses.

Keywords:
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Area of Science:

  • Nanotechnology
  • Biochemistry
  • Analytical Chemistry

Background:

  • Copper nanoclusters (CuNCs) are emerging as versatile nanomaterials.
  • Their synthesis is rapid, cost-effective, and requires minimal manipulation.
  • Tunable fluorescence and low toxicity make CuNCs ideal for sensitive detection.

Purpose of the Study:

  • To review the recent advancements in copper nanocluster synthesis and applications.
  • To explore the use of CuNCs in various biochemical and environmental sensing platforms.
  • To provide a comprehensive overview of CuNCs in fluorometric assays.

Main Methods:

  • Review of literature on CuNC synthesis using various templates (proteins, DNA, etc.).
  • Analysis of CuNC fluorescence properties and their modulation.
  • Compilation of applications in fluorometric assays for biomolecules and environmental analytes.

Main Results:

  • CuNCs demonstrate significant potential in detecting small molecules, proteins, nucleic acids, and drugs.
  • Applications extend to pH sensing and environmental monitoring of metal ions, anions, and pollutants.
  • Diverse synthetic strategies yield CuNCs with tailored optical properties.

Conclusions:

  • Copper nanoclusters represent a powerful tool for advanced biochemical sensing and environmental analysis.
  • Their facile synthesis and unique properties drive innovation in analytical methodologies.
  • Continued research promises expanded applications in diagnostics and environmental monitoring.