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Updated: Jan 20, 2026

Spatial Molecular Imaging of the Glycome Using Mass Spectrometry
Published on: November 28, 2025
Dual polarity MALDI imaging mass spectrometry on the same pixel points reveals spatial lipid localizations at
Ibrahim Kaya1,2, Eva Jennische3, Stefan Lange3
1Department of Chemistry and Molecular Biology , University of Gothenburg , 412 96 , Sweden.
Abstract:
Sensitive laser desorption/ionization obtained via a sublimation-coated 1,5-diaminonaphthalene (1,5-DAN) matrix allowed dual polarity MALDI-IMS analysis on the same pixel points across the jejunal mucosal region in rat small intestine which yielded high-spatial-resolution (10 μm) ion images of several lipid species correlated with the same histological features.
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