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Dose-Response Relationship: Selectivity and Specificity01:25

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Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
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Using Microwave and Macroscopic Samples of Dielectric Solids to Study the Photonic Properties of Disordered Photonic Bandgap Materials10:35

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Disordered structures offer new mechanisms for forming photonic bandgaps and unprecedented freedom in functional-defect designs. To circumvent the computational challenges of disordered systems, we construct modular macroscopic samples of the new class of PBG materials and use microwaves to characterize their scale-invariant photonic properties, in an easy and inexpensive...
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Dose Size and Dosing Frequency: Determination Methods01:21

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Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
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Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

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A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
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Neutron Radiography and Computed Tomography of Biological Systems at the Oak Ridge National Laboratory's High Flux Isotope Reactor10:24

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This manuscript describes a protocol for neutron radiography and computed tomography of biological samples using a High Flux Isotope Reactor (HFIR) CG-1D beamline to measure a metal implant in a rat femur, a mouse lung, and an herbaceous plant root/soil...
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A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
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Related Experiment Video

Updated: Jan 20, 2026

Using Microwave and Macroscopic Samples of Dielectric Solids to Study the Photonic Properties of Disordered Photonic Bandgap Materials
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Low-dose material-specific radiography using monoenergetic photons.

Joseph Harms1,2, Luke Maloney1, Anna Erickson1

  • 1Nuclear and Radiological Engineering and Medical Physics Programs, G. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta GA 30332, United States of America.

Plos One
|September 7, 2019
PubMed
Summary
This summary is machine-generated.

Monoenergetic photon beams offer improved cargo container radiography, reducing radiation dose and enhancing image quality for security screening. This advanced imaging technique addresses limitations of current methods for detecting illicit materials.

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Area of Science:

  • Nuclear physics
  • Imaging science
  • Global trade security

Background:

  • Global trade relies heavily on cargo containers, increasing security risks from smuggled nuclear materials.
  • Current radiographic inspection methods using bremsstrahlung beams are limited by low penetration and high radiation dose.
  • Existing techniques face challenges with dense cargoes and security threats.

Purpose of the Study:

  • To evaluate the efficacy of monoenergetic photon beams for cargo container radiography.
  • To demonstrate improvements in radiation dose reduction and image quality compared to conventional methods.
  • To enhance the detection capabilities for shielded special nuclear material in shipping containers.

Main Methods:

  • Utilizing Monte Carlo simulations for realistic imaging scenarios.
  • Incorporating support from previous experimental measurements.
  • Applying dual-energy methods for material atomic number calculation.
  • Assessing image quality through noise standard deviation, contrast-to-noise ratio, and pixel error.

Main Results:

  • Monoenergetic photon beams significantly reduce radiation dose to cargo and potential stowaways.
  • Demonstrated enhancement in image quality, including better penetration through dense materials.
  • Dual-energy methods effectively determine material atomic number for improved threat assessment.
  • Image quality metrics show positive correlation with beam energy and detector setup.

Conclusions:

  • Monoenergetic photon beams present a viable alternative for enhanced cargo container security screening.
  • This technology can overcome the limitations of current bremsstrahlung-based radiography.
  • Improved imaging capabilities contribute to mitigating the risks of nuclear smuggling in global trade.