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Updated: Jan 20, 2026

Labeling hESCs and hMSCs with Iron Oxide Nanoparticles for Non-Invasive in vivo Tracking with MR Imaging
Published on: March 31, 2008
Transferrin-Conjugated Superparamagnetic Iron Oxide Nanoparticles as In Vivo Magnetic Resonance Imaging Contrast
Jun Wang1, Baolin Zhang1, Gao Yang1
1Key Laboratory of Nonferrous and Materials Processing Technology, Ministry of Education, College of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, Guangxi, China.
Abstract:
Poly(ethylene glycol) (PEG)/poly(ethylene imine) (PEI) modified superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by the thermal decomposition of iron (III) acetylacetonate (Fe(acac)₃) in PEG containing PEI. Transferrin (Tf) was employed to functionalize SPIONs. The potential of Tf-SPIONs as brain magnetic resonance (MR) imaging contrast agents was explored by using Kunming mice as an animal model. The in vivo experiments revealed that Tf-SPIONs exhibited an enhanced contrast time as compared with the PEG-SPIONs and PEG/PEI-SPIONs. Tf-SPIONs exhibit promising potential for bioimaging applications because of their advantages of dispersibility in water, low cytotoxicity and long circulation time in blood.
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