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Related Experiment Video

Updated: Jan 19, 2026

Author Spotlight: Implementing the Enhanced Recovery After Surgery Concept in Rehabilitation Following Anterior Cruciate Ligament Reconstruction
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Can initial sarcopenia affect poststroke rehabilitation outcome?

Yongjun Jang1, Sun Im2, Yeonjae Han2

  • 1Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|September 10, 2019
PubMed
Summary
This summary is machine-generated.

Sarcopenia, or muscle loss, detected early after stroke significantly increases the risk of poor functional recovery. This risk is notably higher for women, indicating a need for targeted interventions.

Keywords:
Hand strengthHemiplegiaRecovery of functionSarcopeniaSexStroke

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Area of Science:

  • Rehabilitation Medicine
  • Neurology
  • Geriatrics

Background:

  • Stroke frequently leads to long-term disability and impaired functional recovery.
  • Sarcopenia, characterized by loss of muscle mass and strength, is increasingly recognized as a significant factor affecting post-stroke outcomes.
  • Early identification of factors predicting functional recovery is crucial for effective rehabilitation strategies.

Purpose of the Study:

  • To investigate the association between sarcopenia and functional recovery at six months post-stroke.
  • To determine if sarcopenia predicts poor functional outcomes, particularly in relation to sex differences.

Main Methods:

  • Retrospective cohort analysis of 194 hemiplegic stroke patients.
  • Sarcopenia assessed by nonhemiplegic grip strength within two weeks of stroke.
  • Functional recovery measured using the modified Rankin Scale (mRS) at six months.

Main Results:

  • 72.2% of patients experienced poor functional recovery (mRS >3) at six months.
  • Sarcopenia was more prevalent in patients with poor functional recovery (men: 51.3%, women: 42.2%).
  • Sarcopenia was associated with a 2.61-fold increased risk of poor functional outcome, with a significantly stronger association in women (OR=9.93).

Conclusions:

  • Early detection of sarcopenia post-stroke is a significant predictor of poor functional recovery.
  • Women with sarcopenia within two weeks of stroke onset face a substantially higher risk of poor long-term functional outcomes.
  • These findings highlight the importance of assessing and managing sarcopenia in stroke rehabilitation, especially in women.