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A supramolecular sensor array for selective immunoglobulin deficiency analysis

Yang Liu1, Adam D Gill2, Yaokai Duan3

  • 1University of California - Riverside, Environmental Toxicology Program, Riverside, CA 92521, USA. wenwan.zhong@ucr.edu.

Chemical Communications (Cambridge, England)
|September 10, 2019
PubMed

A host-guest based fluorescence sensor array can sense small differences in protein structure. The combination of three cavitand hosts and two fluorophores to form a 4-component array is sufficient to fully discriminate five structurally similar Ig protein isotypes. The array can be applied to recognize Ig deficiencies in serum, when combined with a Protein L-based extraction process, allowing analysis of immunodeficiency in a simpler, lower cost manner than tests that require multiple specific antibodies.

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