Related Experiment Video
Updated: Jan 19, 2026
High-Resolution Comparison of Bacterial Conjugation Frequencies
Published on: January 10, 2019
Comparison of MRI Properties between Multimeric DOTAGA and DO3A Gadolinium-Dendron Conjugates
Maleotane Ndiaye1, Volodymyr Malytskyi2, Thomas Vangijzegem1
1Laboratoire de RMN et d'Imagerie Moléculaire , Université de Mons , B-7000 Mons , Belgium.
Abstract:
The inherent lack of sensitivity of MRI needs the development of new Gd contrast agents in order to extend the application of this technique to cellular imaging. For this purpose, two multimeric MR contrast agents obtained by peptidic coupling between an amido amine dendron and GdDOTAGA chelates (premetalation strategy, G1-4GdDOTAGA) or DO3A derivatives which then were postmetalated (G1-4GdDO3A) have been prepared. By comparison to the monomers, an increase of longitudinal relaxivity has been observed for both structures. Especially for G1-4GdDO3A, a marked increase is observed between 20 and 60 MHz. This structure differs from G1-4GdDOTAGA by an increased rigidity due to the aromatic linker between each chelate and the organic framework. This has the effect of limiting local rotational movements, which has a positive impact on relaxivity.
Related Concept Videos
05:18High-Resolution Comparison of Bacterial Conjugation Frequencies
05:15An Aptamer-based Sensor for Unchelated Gadolinium(III)
02:50Conjugated Proteins
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
02:44Non-Reducing SDS PAGE: A Method to Analyze Disulfide-Linked Multimeric Protein Complexes
10:46MRI and PET in Mouse Models of Myocardial Infarction
01:19Conjugation